RNAlater is a liquid non-toxic animal tissue preservation reagent. It can quickly penetrate into tissue cells and protect non-frozen cellular RNA from degradation by effectively inhibiting RNase activity, so that after the tissue sample is obtained, it is not necessary to process the sample immediately, and it is not necessary to freeze the sample in liquid nitrogen,so it is more convenient for subsequent experimental operations. The use of tissue RNA protection solution can avoid the inconvenience of using liquid nitrogen or ultra-low temperature refrigerators, and storing different batches of tissue specimens in the protection solution can immediately stop and fix the sequence changes of RNA expression, which can reduce the error between experimental groups .

RNAlater can be widely used in a variety of vertebrate samples, including brain, heart, kidney, spleen, liver, and lung. After fresh non-frozen tissues are immersed in Buffer RNAlater at a ratio of 1:10, the samples can be stored at room temperature for 1 week, 37°C for 1 day, 4°C for at least 1 month; tissues can be immersed at 4°C at -20°C or  store at -80℃ for a long time.